Well, I think Talwyn will be in A4O just because of that. Why would Cronk and Zephyr be there completely on their own, unless (spoilers from the Comic series incoming)
they are set to rescue Ratchet like in the Issue 2.
But what I wonder is how IG is going to explain the events of the R&C Comic series at the beginning. I think they can't do a through explanation, because the comics were actually quite long story-wise. Maybe they'll include the comics as skill point rewards like concept art in the past games, or then just make it like in aCiT, where some of the characters explains what happened.
Because "change" haunts them.
That's just what happened to Crash Bandicoot in Crash Twinsanity. The idea of a free-roaming Crash game where he teams up with his nemesis N. Cortex was just too much for some of the fans. Ironically, most of the haters said later that it was a good game compared to the new Radical Entertainment-made games which changed the series' formula completely.