I was really not worried about this not being a sequel to Nexus after what we've seen. But all the better to have confirmation.
Playing as Mysterious Female Ratchet... figured. When I'm playing a Sly game, I always do Murray and Bentley missions first real quick so I can go back to playing Sly. That has to do with Sly having the coolest mechanics, while the others feel downgraded. From the prosthetic arm and hammer I estimate FemRatchet's going to have more up close combat, whereas Ratchet will rely on ranged weapons mostly.